Professor Ciclitira undertakes research into coeliac and inflammatory bowel disease. Investigation of coeliac disease involves studying (i) Identification of the toxic fractions in cereals, (ii) developing assays to quantify coeliac toxic fraction in foods for individuals with coeliac disease (iii) studying the disease mechanisms (iv) developing novel variants cereals of wheat, barley and rye which are non-toxic to individuals with coeliac disease but which retain the nutritional and baking qualities of the original cultivars. Research in inflammatory bowel disease involves studying the disease mechanisms including the role of bacteria in the development of ulcerative colitis and pouchitis, a condition that affects individuals who have had an ileoanal pouch fashioned after a total colectomy for ulcerative colitis.
Most relevant publications:
We are unable to provide re-prints
Ciclitira P J, Dewar D H, McLaughlin S D, Sanders DS (2012): The management of adults with coeliac disease, British Society of Gastroenterology
Ciclitira P J (2012): Management of celiac disease in Adults; Up To Date
Zevallos VF, Ellis HJ, Suligoj T, Herencia LI, Ciclitira PJ (2012): Variable activation of immune response by quinoa (Chenopodium quinoa Willd.) prolamins in celiac disease. Am J Clin Nutr. 2012 Aug;96(2):337-44
David H Dewar; Suzanne C Donnelly; Simon D McLaughlin; Matthew W Johnson; H Julia Ellis; Paul J Ciclitira (2012): Celiac disease: Management of persistent symptoms in patients on a gluten-free diet. World J. Gastroenterol. 18, 1348
Donnelly S C, Ho-Yen C, Mitchell T, Chang Fuju, Ciclitira PJ (2012): Treatment of type 2 refractory coeliac disease in a single centre. Proceeding of the 25th Prolamin Analysis Group Meeting, Edited by Peter Koehler, Verlag Deutsche Forschungsanstalt fur Lebensmittelchemie.
Ellis HJ, Lozano-Sanchez P, Bermudo Redondo C, Suligoj T, Biagi F, Bianchi PI, Corazza GR, De Silvestri A, Bravi E, Katakis I, O'Sullivan CK, Ciclitira PJ (2012:Antibodies to Wheat High-Molecular-Weight Glutenin Subunits in Patients with Celiac Disease. Int Arch Allergy Immunol. 2012 Jul 17;159(4):428-434
Landy J, Al-Hassi HO, McLaughlin SD, Knight SC, Ciclitira PJ, Nicholls RJ, Clark SK, Hart AL (2012): Etiology of pouchitis. Inflammatory Bowel Disease, Oct 21 doi 10.1002/1bd. 21911 Epub ahead of print.
McLaughlin SD, Culkin A, Cole J, Clark SK, Tekkis PP, Ciclitira PJ, Nicholls RJ, Whelan K (2012): Exclusive elemental diet impacts on the gastrointestinal microbiota and improves symptoms in patients with chronic pouchitis. J Crohn's Colitis. 2012 Aug 1
Donnelly SC, Ellis HJ, Ciclitira PJ. Pharmacotherapy and management strategies for coeliac disease. Expert. Opin. Pharmacother. 2011 Aug; 12(11):1731-44
D'Souza, FR; Lim, M; Hainsworth, A; Mahadeva, U; Ciclitira, PJ; Carapeti E (2011): A case of squamous cell carcinoma in an ileoanal pouch.Colorectal Dis 13, 3140
Landy J, Al-Hassi HO, McLauglin SD, Walker AW, Ciclitira PJ, Nicholls RJ, Clark SK, Hart AL (2011): Faecal transplantation therapy for gastrointestinal disease; Ail.Pharmacol.Ther. 34(4): 409-415
McLaughlin SD, Clark SK, Tekkis PP, Ciclitira PJ, Nicholls RJ (2011): An open study of maintenance antibiotic therapy of chronic antibiotic dependent pouchitis, efficacy, complications and outcome. Colorectal Dis. 13:438-444
Zimmer KP, Fischer I, Mothes T, Weissen-Plenz G, Schmitz M, Wieser H, Büning J, Lerch MM, Ciclitira PJ, Weber P, Naim HY (2010): Endocytotic segregation of gliadin peptide 31-49 in enterocytes. Gut. 59(3):300-10.
- Prof. Paul J Ciclitira -
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